Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431676 | 0.77 | METAP1 (0.42) | HTR2CHTR2AMETAP1CHRM2CHRM4 | |
| SCHEMBL3859853 | 0.76 | PTGS2 (0.48) | HTR2CHTR2AMETAP1KMT2AGAA | |
| SCHEMBL3869414 | 0.76 | METAP1 (0.42) | HTR2CHTR2AMETAP1CHRM2CHRM4 | |
| SCHEMBL9730321 | 0.75 | METAP1 (0.50) | HTR2CHTR2AMETAP1CHRM2CHRM4 | |
| SCHEMBL6936252 | 0.75 | METAP1 (0.43) | HTR2CHTR2AMETAP1KMT2AGAA | |
| SCHEMBL7605900 | 0.73 | AKR1C3 (0.51) | METAP1KMT2AGAAMEN1SMN1; SMN2 | |
| SCHEMBL13969778 | 0.73 | METAP1 (0.57) | HTR2CHTR2AMETAP1KMT2AGAA | |
| SCHEMBL11761342 | 0.72 | METAP1 (0.45) | HTR2CHTR2AMETAP1KMT2AGAA | |
| SCHEMBL7409039 | 0.71 | FFAR1 (0.44) | METAP1GAAALDH1A1HPGDKDM4E | |
| SCHEMBL11811157 | 0.70 | ALDH1A1 (0.43) | METAP1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142801-B1 | INDENE DERIVATIVES USEFUL AS PAF-ANTAGONISTS | MERCK & CO. INC. (US) | 1989-05-31 | — | — | EP | disclosed |