Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608201 | 0.82 | CCNA2 (0.44) | CHRM4CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL10605822 | 0.82 | CHRM4 (0.44) | CHRM4CCNA2CDK2KMT2A | |
| SCHEMBL10628206 | 0.82 | ALDH1A1 (0.43) | CHRM4CCNA2CDK2ALDH1A1KMT2A | |
| SCHEMBL9484144 | 0.72 | MAP2K1 (0.48) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL29915528 | 0.72 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL1242243 | 0.72 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL10662778 | 0.71 | CHRM4 (0.57) | CHRM4CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL10473732 | 0.71 | MEN1 (0.53) | CCNA2CDK2ALDH1A1GAAKMT2A | |
| SCHEMBL10628308 | 0.71 | ESR1 (0.44) | ALDH1A1GAAKMT2A | |
| Hydrochloric Acid SCHEMBL27841975 | 0.70 | ALDH1A1 (0.68) | MAP2K1ALDH1A1APPGAAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020730-C | PREPARING METHOD FOR THIAZOLKETONE ADDITIVE | MERRELL DOW PHARMA (US) | 1993-05-19 | — | — | CN | disclosed |
| EP-0219625-B1 | CARDIOTONIC HETEROCYCLOCARBONYL- AND ACETYL-THIAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0219625-A1 | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-29 | — | — | EP | disclosed |
| CN-86104968-A | Cardiotonic heterocyclic carbonyl and acetyl thiazolones | — | 1987-04-22 | — | — | CN | disclosed |
| US-4623651-A | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-11-18 | — | — | US | disclosed |