Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608205 | 0.82 | CHRM4 (0.48) | CCNA2CDK2CHRM4CDK5CDK5R1 | |
| SCHEMBL7434193 | 0.76 | PDE3B (0.70) | NPC1RAB9ASMN1; SMN2MAP2K1ALDH1A1 | |
| SCHEMBL10474704 | 0.75 | HTR7 (0.41) | CCNA2CDK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5089702 | 0.70 | MAP2K1 (0.51) | POLBNPC1RAB9ASMN1; SMN2MAP2K1 | |
| SCHEMBL9484144 | 0.69 | MAP2K1 (0.48) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL1242243 | 0.69 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL29915528 | 0.69 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL10829884 | 0.68 | SMN1; SMN2 (0.64) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27841975 | 0.67 | ALDH1A1 (0.68) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL10662778 | 0.66 | CHRM4 (0.57) | CCNA2CDK2POLBCHRM4CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020730-C | PREPARING METHOD FOR THIAZOLKETONE ADDITIVE | MERRELL DOW PHARMA (US) | 1993-05-19 | — | — | CN | disclosed |
| EP-0219625-B1 | CARDIOTONIC HETEROCYCLOCARBONYL- AND ACETYL-THIAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0219625-A1 | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-29 | — | — | EP | disclosed |
| CN-86104968-A | Cardiotonic heterocyclic carbonyl and acetyl thiazolones | — | 1987-04-22 | — | — | CN | disclosed |
| US-4623651-A | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-11-18 | — | — | US | disclosed |