⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143238 | 0.68 | — | — | |
| SCHEMBL3999555 | 0.65 | — | — | |
| SCHEMBL10609471 | 0.65 | — | — | |
| SCHEMBL7215917 | 0.62 | — | — | |
| SCHEMBL6904577 | 0.61 | MPO (0.36) | — | |
| SCHEMBL9851251 | 0.60 | ALDH1A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL18422639 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL31717928 | 0.59 | ALDH1A1 (0.30) | — | |
| SCHEMBL29394145 | 0.59 | — | — | |
| SCHEMBL4146881 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766130-A | 2-phenyl-imidazopyridin-ones and also useful as cardiotonics and anti-hypertensives | CELAMERCK GMBH & CO. KG (DE) | 1988-08-23 | — | — | US | claimed |
| EP-0184738-A2 | Imidazole derivatives, medicaments containing these compounds, and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-06-18 | — | — | EP | claimed |
| EP-0130461-A2 | Imidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-01-09 | — | — | EP | claimed |
| US-12252495-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2025-03-18 | — | — | US | disclosed |
| CN-118355004-A | Cyclopropyl- (heteroaryl) -substituted ethylsulfonyl-pyridine derivatives | 勃林格殷格翰动物保健有限公司 | 2024-07-16 | — | — | CN | disclosed |
| US-20240109902-A1 | PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2024-04-04 | — | — | US | disclosed |
| US-11760760-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2023-09-19 | — | — | US | disclosed |
| US-20220220116-A1 | PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2022-07-14 | — | — | US | disclosed |
| US-11236095-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2022-02-01 | — | — | US | disclosed |
| US-4766130-A | 2-phenyl-imidazopyridin-ones and also useful as cardiotonics and anti-hypertensives | CELAMERCK GMBH & CO. KG (DE) | 1988-08-23 | — | — | US | disclosed |
| US-4670438-A | Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents | DR. KARL THOMAE GMBH (DE) | 1987-06-02 | — | — | US | disclosed |
| EP-0184738-A2 | Imidazole derivatives, medicaments containing these compounds, and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-06-18 | — | — | EP | disclosed |
| EP-0130461-A2 | Imidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-01-09 | — | — | EP | disclosed |