Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 19/20 | 0.77 |
| ▸ | TOP1 | P11387 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061140 | 1.00 | PRF1 (0.77) | PRF1TOP1 | |
| SCHEMBL12634251 | 0.87 | PRF1 (1.00) | PRF1TOP1 | |
| SCHEMBL14761474 | 0.87 | PRF1 (1.00) | PRF1TOP1 | |
| SCHEMBL2022040 | 0.87 | PRF1 (1.00) | PRF1TOP1 | |
| SCHEMBL2022038 | 0.87 | PRF1 (1.00) | PRF1TOP1 | |
| SCHEMBL2022037 | 0.87 | PRF1 (1.00) | PRF1TOP1 | |
| SCHEMBL13056365 | 0.87 | PRF1 (0.60) | PRF1TOP1 | |
| SCHEMBL5142516 | 0.87 | PRF1 (0.82) | PRF1TOP1 | |
| SCHEMBL5142515 | 0.87 | PRF1 (0.82) | PRF1TOP1 | |
| SCHEMBL2038859 | 0.86 | PRF1 (1.00) | PRF1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7294641-B2 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | L'OREAL (FR) | 2007-11-13 | — | — | US | disclosed |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2006-02-16 | — | — | US | disclosed |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | KRT18, FGF1, SHH | PRF1 2632/4885TOP1 879/4885 |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | COX15, HPGD, TYR | PRF1 3750/4885TOP1 2749/4885 |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | COX15, HPGD, TYR | PRF1 3750/4885TOP1 2749/4885 |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | KRT18, SHH, FGF1 | PRF1 4111/4885TOP1 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.