Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618179 | 1.00 | LMNA (0.55) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL13466026 | 0.92 | LMNA (0.60) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL10618215 | 0.92 | LMNA (0.60) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL12837364 | 0.92 | LMNA (0.60) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL10618219 | 0.92 | LMNA (0.60) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL11391185 | 0.88 | LMNA (0.54) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL10618200 | 0.88 | LMNA (0.54) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL10618206 | 0.88 | LMNA (0.54) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL11391188 | 0.88 | LMNA (0.54) | LMNAKMT2ATSHRPOLBALDH1A1 | |
| SCHEMBL10937469 | 0.88 | LMNA (0.54) | LMNAKMT2ATSHRPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141057-B1 | NOVEL 4'-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1988-08-31 | — | — | EP | disclosed |
| US-4547567-A | ANTICARCINOGENIC, ANTITUMOR AGENTS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-10-15 | — | — | US | disclosed |
| EP-0141057-A1 | Novel 4'-demethyl-4-epipodophyllotoxin derivatives, a process for their preparation and their use as medicaments | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1985-05-15 | — | — | EP | disclosed |