Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 12/20 | 0.39 |
| ▸ | FAP | Q12884 | 4/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | FECH | P22830 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3879313 | 0.93 | CHRNB2 (0.39) | CHRNB2CHRNA4SLC2A1SLC2A3DPP4 | |
| SCHEMBL13866969 | 0.88 | DPP4 (0.41) | DPP4FAPKCNH2DPP9 | |
| SCHEMBL13866963 | 0.84 | DPP4 (0.48) | SLC2A1SLC2A3DPP4FAPKCNH2 | |
| SCHEMBL13866961 | 0.84 | DPP4 (0.41) | CHRNB2CHRNA4SLC2A1SLC2A3DPP4 | |
| SCHEMBL13866981 | 0.83 | DPP4 (0.43) | DPP4FAPKCNH2DPP9 | |
| SCHEMBL13866987 | 0.82 | DPP4 (0.42) | DPP4FAPKCNH2DPP9 | |
| Trifluoroacetic Acid SCHEMBL3888334 | 0.82 | DPP4 (0.36) | DPP4FAPDPP9 | |
| SCHEMBL13866966 | 0.81 | DPP4 (0.41) | DPP4FAPKCNH2DPP9 | |
| SCHEMBL13866972 | 0.80 | DPP4 (0.40) | DPP4FAPKCNH2DPP9 | |
| SCHEMBL13867026 | 0.79 | DPP4 (0.56) | DPP4FAPDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2993239-A1 | METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS | AstraZeneca AB (SE) | 2016-03-09 | — | — | EP | disclosed |
| US-20110152340-A1 | Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-23 | — | — | US | disclosed |
| EP-2281069-A2 | METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-02-09 | — | — | EP | disclosed |
| US-20110020797-A1 | Methods For Identifying Patients With An Increased Likelihood Of Responding To DPP-IV Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-01-27 | — | — | US | disclosed |
| WO-2009140685-A2 | METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |
| US-7524847-B2 | Fused 1,3-dihydro-imidazole ring compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |
| WO-2008098256-A1 | METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152340-A1 | Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors | DPP4, DPP3, DPP7 | CHRNB2 927/4885CHRNA4 321/4885SLC2A1 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.