Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29387324 | 0.86 | GFER (0.63) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL244238 | 0.86 | GFER (0.63) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL10625378 | 0.80 | GFER (0.39) | GFERMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL397442 | 0.79 | GFER (0.54) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL11309320 | 0.78 | GFER (0.53) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL4843540 | 0.78 | ALDH1A1 (0.61) | GFERMAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11594933 | 0.77 | GFER (0.53) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL9365623 | 0.77 | ALDH1A1 (0.52) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL18831066 | 0.77 | GFER (0.52) | GFERMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL6888931 | 0.77 | GFER (0.52) | GFERMAPTLMNAUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168661-B1 | AMINOPYRAZOLINONES, THEIR PREPARATION AND USE | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | claimed |
| US-4737458-A | STABILITY | BOEHRINGER MANNHEIM GMBH (DE) | 1988-04-12 | — | — | US | claimed |
| EP-0168661-A1 | Aminopyrazolinones, their preparation and use | Roche Diagnostics GmbH (DE) | 1986-01-22 | — | — | EP | claimed |
| EP-0168661-B1 | AMINOPYRAZOLINONES, THEIR PREPARATION AND USE | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |
| US-4737458-A | STABILITY | BOEHRINGER MANNHEIM GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0168661-A1 | Aminopyrazolinones, their preparation and use | Roche Diagnostics GmbH (DE) | 1986-01-22 | — | — | EP | disclosed |