Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.53 |
| ▸ | DRD1 | P21728 | 8/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.53 |
| ▸ | DRD4 | P21917 | 6/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10620912 | 0.89 | DRD2 (0.58) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10620758 | 0.87 | HRH4 (0.47) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10625693 | 0.87 | PAK1 (0.49) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10620821 | 0.86 | HRH4 (0.46) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10623820 | 0.86 | DRD2 (0.61) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10625295 | 0.86 | PAK1 (0.48) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10620991 | 0.83 | HRH4 (0.56) | DRD2DRD1HRH4DRD4LMNA | |
| SCHEMBL11446142 | 0.82 | DRD2 (0.37) | DRD2DRD1HRH4DRD4CHRM1 | |
| Hydrochloric Acid SCHEMBL11445376 | 0.81 | DRD2 (0.36) | DRD2DRD1HRH4DRD4CHRM1 | |
| SCHEMBL10674331 | 0.81 | HRH4 (0.45) | DRD2DRD1HRH4DRD4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761412-A | Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for the treatment of psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | claimed |
| US-4663453-A | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-05 | — | — | US | claimed |
| US-4764616-A | ANALGESIC, ANTIPHYCHOTIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-16 | — | — | US | disclosed |
| US-4761412-A | Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for the treatment of psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4761411-A | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4723003-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4723007-A | ANALGESICS, ANTIPSYCHOTIC AGENTS; INTERMEDIATES FOR PROCESSING | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4663453-A | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0129692-A2 | Dibenzodiazepin derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-01-02 | — | — | EP | disclosed |