Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | DRD1 | P21728 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11445376 | 0.99 | DRD2 (0.36) | DRD2DRD1PDE4DPDE4APDE4B | |
| SCHEMBL10624311 | 0.82 | DRD2 (0.53) | DRD2DRD1PDE4DMAPK1DRD4 | |
| Hydrochloric Acid SCHEMBL11453531 | 0.81 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL11445988 | 0.81 | SMN1; SMN2 (0.39) | MAPK1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11446317 | 0.80 | SMN1; SMN2 (0.38) | MAPK1LMNASMN1; SMN2 | |
| SCHEMBL11446365 | 0.74 | TRPA1 (0.33) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| Hydrochloric Acid SCHEMBL11453532 | 0.73 | LMNA (0.33) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL10625693 | 0.71 | PAK1 (0.49) | DRD2DRD1PDE4DDRD4HTR2A | |
| SCHEMBL10620758 | 0.71 | HRH4 (0.47) | DRD2DRD1PDE4DMAPK1DRD4 | |
| SCHEMBL10623820 | 0.70 | DRD2 (0.61) | DRD2DRD1MAPK1DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | claimed |