Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.77 |
| ▸ | ABL1 | P00519 | 2/20 | 0.77 |
| ▸ | ABL2 | P42684 | 1/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060869 | 0.87 | EGFR (1.00) | EGFRABL1ABL2ABCB1MEN1 | |
| SCHEMBL3355884 | 0.87 | EGFR (1.00) | EGFRABL1ABL2ABCB1MEN1 | |
| SCHEMBL13640743 | 0.81 | MEN1 (0.65) | EGFRABL1ABL2ABCB1MEN1 | |
| SCHEMBL10620481 | 0.80 | SMN1; SMN2 (0.76) | EGFRABL1ABCB1MEN1KMT2A | |
| SCHEMBL10561646 | 0.76 | EGFR (0.74) | EGFRABL1ABL2ABCB1SMN1; SMN2 | |
| SCHEMBL12892701 | 0.76 | RAB9A (0.81) | EGFRABL1ABCB1MEN1KMT2A | |
| SCHEMBL29085510 | 0.75 | SMN1; SMN2 (0.79) | EGFRABL1ABL2ABCB1MEN1 | |
| SCHEMBL30527884 | 0.75 | SMN1; SMN2 (0.79) | EGFRABL1ABL2ABCB1MEN1 | |
| SCHEMBL10622209 | 0.73 | EGFR (0.77) | EGFRABL1ABL2MEN1KMT2A | |
| SCHEMBL12289060 | 0.72 | MAPT (0.81) | EGFRABL1ABL2ABCB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772627-A | AMORPHOUS DRUG AND ADSORBENT, IMPROVED DISSOLUTION AND ADSORPTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0129893-A2 | Ground mixture | Takeda Chemical Industries, Ltd. (JP) | 1985-01-02 | — | — | EP | disclosed |