Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | NPC1 | O15118 | 6/20 | 0.76 |
| ▸ | RAB9A | P51151 | 6/20 | 0.76 |
| ▸ | TP53 | P04637 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.76 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.76 |
| ▸ | POLB | P06746 | 3/20 | 0.76 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640743 | 0.93 | MEN1 (0.65) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL554056 | 0.87 | MAPT (1.00) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL29352944 | 0.87 | MAPT (1.00) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL19166 | 0.87 | MAPT (1.00) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL12892701 | 0.87 | RAB9A (0.81) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL10026577 | 0.86 | MAPT (0.81) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL551352 | 0.85 | MAPT (0.97) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL551449 | 0.85 | MAPT (0.97) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL38650814 | 0.85 | MAPT (0.97) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| Genistein SCHEMBL551402 | 0.85 | MAPT (0.97) | SMN1; SMN2MAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742141-B2 | Inhibition and treatment of prostate cancer metastasis | NORTHWESTERN UNIVERSITY (US) | 2014-06-03 | — | — | US | disclosed |
| US-20130296582-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| US-20120283313-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | NORTHWESTERN UNIVERSITY (US) | 2012-11-08 | — | — | US | disclosed |
| US-7880059-B2 | Production of proanthocyanidins to improve forage quality | THE SAMUEL ROBERTS NOBLE FOUNDATION (US) | 2011-02-01 | — | — | US | disclosed |
| US-20090083874-A1 | PRODUCTION OF PROANTHOCYANIDINS TO IMPROVE FORAGE QUALITY | THE SAMUEL ROBERTS NOBLE FOUNDATION | 2009-03-26 | — | — | US | disclosed |
| US-4772627-A | AMORPHOUS DRUG AND ADSORBENT, IMPROVED DISSOLUTION AND ADSORPTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0129893-A2 | Ground mixture | Takeda Chemical Industries, Ltd. (JP) | 1985-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090083874-A1 | PRODUCTION OF PROANTHOCYANIDINS TO IMPROVE FORAGE QUALITY | QPCTL, FABP6, HHAT | SMN1; SMN2 4806/4885MAPT 2155/4885MEN1 2562/4885 |
| US-20130296582-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | MAPK4, MAP4K4, MAP3K4 | SMN1; SMN2 4692/4885MAPT 2493/4885MEN1 302/4885 |
| US-20120283313-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | MAPK4, MAP4K4, MAP3K4 | SMN1; SMN2 4692/4885MAPT 2493/4885MEN1 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.