Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28209917 | 0.97 | CYP3A4 (0.65) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL10630113 | 0.97 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119826 | 0.97 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL27902546 | 0.95 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8815336 | 0.95 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9022606 | 0.95 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119824 | 0.89 | LMNA (0.67) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3788610 | 0.87 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2222247 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686208 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947279-A | Pig farm manure cleaning process suitable for full-quantification collection, storage and transportation | 赣州锐源生物科技有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-1494528-A | Benzophenones as reverse transcriptase inhibitors | ʷ��˿�������ȳ�ķ����˾ | 2004-05-05 | — | — | CN | disclosed |
| US-4727197-A | Process for preparing natural benzaldehyde and acetaldehyde natural benzaldehyde and acetaldehyde compositions, products produced thereby and organoleptic utilities therefor | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4727058-A | Process for preparing natural benzaldehyde and acetaldehyde, natural benzaldehyde and acetaldehyde compositions, products produced thereby and organoleptic utilities therefor | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4683342-A | Process for preparing natural benzaldehyde and acetaldehyde, natural benzaldehyde and acetaldehyde compositions, products produced thereby and organoleptic utilities therefor | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1987-07-28 | — | — | US | disclosed |