Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.63 |
| ▸ | GALR3 | O60755 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL119824 | 0.97 | LMNA (0.67) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8815341 | 0.94 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686210 | 0.94 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686208 | 0.94 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL30113090 | 0.92 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL31575663 | 0.89 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316506 | 0.89 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119826 | 0.89 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL10630113 | 0.89 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1052170 | 0.89 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1375545-B1 | CATALYST AND PROCESS FOR THE TRIMERISATION OF ISOCYANATES | VENCOREX FRANCE (FR) | 2016-06-29 | — | — | EP | claimed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | claimed |
| EP-1027380-B1 | CATALYST AND METHOD FOR TRIMERIZATION OF ISOCYANATES | RHODIA CHIMIE SA (FR) | 2003-10-08 | — | — | EP | claimed |
| US-5693599-A | Flux washing agent | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1997-12-02 | — | — | US | claimed |
| US-5538832-A | Developing solution for producing printed circuit boards and a process for producing printed circuit boards wherein the developing solution comprises a quaternary ammonium hydroxide and a quaternary ammonium carbonate | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1996-07-23 | — | — | US | claimed |
| CN-112204065-B | Process for preparing polyisocyanate polymers and polyisocyanurate plastics | 科思创知识产权两合公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-114680199-A | Method for improving frost resistance of flavor oil | 丰益(上海)生物技术研发中心有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110062794-B | Hard coating with high chemical and mechanical resistance | 科思创德国股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-110785449-B | Coloured plastics based on crosslinked polyisocyanates | 科思创德国股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-110446737-B | Formation of coatings by separate application of polyisocyanate composition and crosslinking catalyst | 科思创德国股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-109071762-B | Polyisocyanurate plastic containing siloxane group and method for producing same | 科思创德国股份有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-113631545-A | Polyisocyanurate materials as electrical potting compounds | 科思创知识产权两合公司 | 2021-11-09 | — | — | CN | disclosed |
| US-20130165694-A1 | PROCESS FOR THE SYNTHESIS OF CHOLINE SALTS | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-06-27 | — | — | US | disclosed |
| EP-2516382-A2 | PROCESS FOR THE SYNTHESIS OF CHOLINE SALTS | E.I. Du Pont De Nemours And Company (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084765-A2 | PROCESS FOR THE SYNTHESIS OF CHOLINE SALTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | disclosed |
| US-6166232-A | Process for producing ester quats | AKZO NOBEL NV (NL) | 2000-12-26 | — | — | US | disclosed |
| US-5693599-A | Flux washing agent | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5538832-A | Developing solution for producing printed circuit boards and a process for producing printed circuit boards wherein the developing solution comprises a quaternary ammonium hydroxide and a quaternary ammonium carbonate | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5516928-A | REACTION OF ISOPHORONE AND HYDROGEN CYANIDE USING QUATERNARY AMMONIUM CATALYST | BASF AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | PDK1, PC, PDK4 | LMNA 1770/4885MEN1 1006/4885KMT2A 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.