Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238422 | 0.88 | TNKS (0.56) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| 6,3'-Dimethoxyflavone SCHEMBL516389 | 0.86 | KDM4E (0.82) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| 6,3'-Dimethoxyflavone SCHEMBL30894690 | 0.86 | KDM4E (0.82) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL10632120 | 0.85 | SIGMAR1 (0.56) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL31675975 | 0.84 | MAPT (1.00) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL4649870 | 0.84 | MAPT (1.00) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL977613 | 0.84 | HDAC3 (0.62) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL8934603 | 0.84 | MAPT (0.78) | KDM4EMAPTCYP3A4MAPK1TP53 | |
| SCHEMBL1177191 | 0.83 | TNKS (0.74) | KDM4EMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL10629928 | 0.83 | MAPT (0.75) | KDM4EMAPTCYP3A4MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791136-A | ANTIHYPOXIC AGENTS | BURROUGHS WELLCOME CO. (US) | 1988-12-13 | — | — | US | claimed |
| US-4626431-A | 3*-HYDROXY-OR ALKOXYFLAVONE-6-CARBOXYLIC ACID | BURROUGHS WELLCOME CO. (US) | 1986-12-02 | — | — | US | claimed |
| EP-0142303-A2 | Pharmacologically active benzo - and dibenzo - pyrones and use | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-05-22 | — | — | EP | claimed |
| US-4791136-A | ANTIHYPOXIC AGENTS | BURROUGHS WELLCOME CO. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4626431-A | 3*-HYDROXY-OR ALKOXYFLAVONE-6-CARBOXYLIC ACID | BURROUGHS WELLCOME CO. (US) | 1986-12-02 | — | — | US | disclosed |
| EP-0142303-A2 | Pharmacologically active benzo - and dibenzo - pyrones and use | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-05-22 | — | — | EP | disclosed |