Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 4/20 | 0.48 |
| ▸ | CHRNG | P07510 | 4/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.48 |
| ▸ | CHRND | Q07001 | 4/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.42 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10632109 | 0.92 | CHRND (0.51) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL240780 | 0.90 | CHRNA1 (0.58) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL9090677 | 0.90 | CHRNA1 (0.58) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL9091432 | 0.90 | CHRNA1 (0.58) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL7208901 | 0.89 | CHRND (0.60) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL9089190 | 0.82 | CAPN1 (0.49) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL9089141 | 0.82 | CHRND (0.61) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL212151 | 0.82 | CAPN1 (0.60) | CAPN1CAPN9CTSLCTSBCTSH | |
| SCHEMBL14345716 | 0.78 | CHRNB2 (0.67) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL9088720 | 0.78 | CAPN1 (0.53) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196189-B1 | NOVEL ENZYME INHIBITING SUBSTANCE | TOYO JOZO KABUSHIKI KAISHA (JP) | 1988-12-21 | — | — | EP | disclosed |
| US-4732910-A | GUANIDINO, CARBOXAMIDE, EPOXIDE | TOYO JOZO CO, LTD. (JP) | 1988-03-22 | — | — | US | disclosed |
| EP-0196189-A2 | Novel enzyme inhibiting substance | TOYO JOZO KABUSHIKI KAISHA (JP) | 1986-10-01 | — | — | EP | disclosed |