Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | IGF1R | P08069 | 6/20 | 0.64 |
| ▸ | INSR | P06213 | 3/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.59 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063266 | 1.00 | MEN1 (0.67) | MEN1KMT2AMAPTLMNARECQL | |
| SCHEMBL13388937 | 0.91 | IGF1R (0.64) | MEN1KMT2ACASP3BLMSENP8 | |
| SCHEMBL5144855 | 0.87 | IGF1R (0.74) | MEN1KMT2ACASP3BLMSENP8 | |
| SCHEMBL5144857 | 0.87 | IGF1R (0.74) | MEN1KMT2ACASP3BLMSENP8 | |
| SCHEMBL3899184 | 0.82 | GSK3B (0.62) | MEN1KMT2AMAPTLMNARECQL | |
| SCHEMBL3899187 | 0.82 | GSK3B (0.62) | MEN1KMT2AMAPTLMNARECQL | |
| SCHEMBL5145250 | 0.81 | MEN1 (0.67) | MEN1KMT2ACASP3BLMSENP8 | |
| SCHEMBL5145257 | 0.81 | MEN1 (0.67) | MEN1KMT2ACASP3BLMSENP8 | |
| SCHEMBL5165932 | 0.81 | MAPT (1.00) | MEN1KMT2AMAPTLMNARECQL | |
| SCHEMBL5165923 | 0.81 | MAPT (1.00) | MEN1KMT2AMAPTLMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7294641-B2 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | L'OREAL (FR) | 2007-11-13 | — | — | US | disclosed |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2006-02-16 | — | — | US | disclosed |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | KRT18, FGF1, SHH | MEN1 1498/4885KMT2A 2081/4885MAPT 1418/4885 |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | COX15, HPGD, TYR | MEN1 4707/4885KMT2A 2635/4885MAPT 4331/4885 |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | COX15, HPGD, TYR | MEN1 4707/4885KMT2A 2635/4885MAPT 4331/4885 |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | KRT18, SHH, FGF1 | MEN1 3067/4885KMT2A 2222/4885MAPT 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.