Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7600714 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL2346528 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL2350551 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL6468112 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL5818 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL7600720 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL5817 | 1.00 | — | — | |
| Maleic Acid SCHEMBL28714103 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL10907387 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL5431685 | 0.95 | TSHR (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481878-B1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK OPERATIONS GMBH (DE) | 2024-05-22 | — | — | EP | claimed |
| CN-109476803-B | Amine compositions useful for making polyurethane foams | 赢创运营有限公司 | 2022-04-12 | — | — | CN | claimed |
| US-11021561-B2 | Amine composition useful for making polyurethane foam | EVONIK OPERATIONS GMBH (DE) | 2021-06-01 | — | — | US | claimed |
| EP-3144332-B1 | NEW TRIMER CATALYST ADDITIVES FOR IMPROVING FOAM PROCESSABILITY | EVONIK OPERATIONS GMBH (DE) | 2020-10-21 | — | — | EP | claimed |
| EP-3481878-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | Evonik Degussa GmbH (DE) | 2019-05-15 | — | — | EP | claimed |
| EP-2907515-B1 | SKIN PATCH | HISAMITSU PHARMACEUTICAL CO (JP) | 2019-01-02 | — | — | EP | claimed |
| WO-2018013590-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK DEGUSSA GMBH (DE) | 2018-01-18 | — | — | WO | claimed |
| US-20180009930-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK OPERATIONS GMBH (DE) | 2018-01-11 | — | — | US | claimed |
| US-9789188-B2 | Patch | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2017-10-17 | — | — | US | claimed |
| EP-3144332-A1 | NEW TRIMER CATALYST ADDITIVES FOR IMPROVING FOAM PROCESSABILITY | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2017-03-22 | — | — | EP | claimed |
| US-20070259982-A1 | Trimer catalysts with improved processability and surface cure | EVONIK OPERATIONS GMBH (DE) | 2007-11-08 | — | — | US | claimed |
| US-20070259773-A1 | Trimer catalyst additives for improving foam processability | EVONIK OPERATIONS GMBH (DE) | 2007-11-08 | — | — | US | claimed |
| EP-1852449-A2 | New trimer catalyst with improved processability and surface cure | Air Products and Chemicals, Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1852450-A2 | New trimer catalyst additives for improving foam processability | Air Products and Chemicals, Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| EP-0538050-B1 | Process for producing streptovaricin C | SHINETSU BIO INC (US) | 1997-05-14 | — | — | EP | claimed |
| US-5242815-A | Process for preparation of streptovaricin | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1993-09-07 | — | — | US | claimed |
| US-5208153-A | Culturing Streptomyces spectabilis | SHIN-ETSU BIO, INC. (US) | 1993-05-04 | — | — | US | claimed |
| EP-0538050-A2 | Process for producing streptovaricin C | SHIN-ETSU BIO, Inc. (US) | 1993-04-21 | — | — | EP | claimed |
| US-5126254-A | Culturing Streptomyces in presence of nonionic adsorbent | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-06-30 | — | — | US | claimed |
| US-5114846-A | Culture of streptomyces and selecting the asprogenous colonies | SHIN-ETSU BIO, INC. (US) | 1992-05-19 | — | — | US | claimed |