Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7600714 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL2346528 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL2350551 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL6468112 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL106351 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL5818 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL7600720 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL28714103 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL10907387 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL5431685 | 0.95 | TSHR (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3568 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260097044-A1 | ION PAIR LIQUID CRYSTAL FORMULATIONS FOR LONG-ACTING INJECTABLES OF POORLY SOLUBLE DRUGS | FORDOZ PHARMA CORP. (US) | 2026-04-09 | — | — | US | claimed |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | MIGHTY FIRE BREAKER LLC (US) | 2026-01-15 | — | — | US | claimed |
| EP-4651722-A1 | A BIO-PRESERVATION STICKER, METHODS OF PRODUCING THE SAME AND USES THEREOF | Liva Bio Protection Technologies Ltd (IL) | 2025-11-26 | — | — | EP | claimed |
| EP-4646583-A1 | POTASSIUM MALEATE BUFFER FOR FREE CHLORINE ANALYSIS | Hach Company (US) | 2025-11-12 | — | — | EP | claimed |
| US-20250268824-A1 | METHODS FOR MAKING REDUCED PARTICLE SIZE COMPOUNDS | TAP PHARMACEUTICALS AG (CH) | 2025-08-28 | — | — | US | claimed |
| US-20250268918-A1 | METHODS FOR MAKING REDUCED PARTICLE SIZE COMPOUNDS | TAP PHARMACEUTICALS, AG (CH) | 2025-08-28 | — | — | US | claimed |
| EP-4540326-A1 | STORAGE STABILIZATION AGENT FOR STABILIZING AQUEOUS COMPOSITIONS, PROCESS FOR STABILIZING AND USES THEREOF | Omya International AG (CH) | 2025-04-23 | — | — | EP | claimed |
| CN-119421931-A | Storage stabilizer for stabilizing aqueous compositions, method for stabilizing same and use thereof | 欧米亚国际集团 | 2025-02-11 | — | — | CN | claimed |
| CN-119280450-A | Medical fabric dressing with long-acting disinfection and sterilization functions and preparation method thereof | 孙国明 | 2025-01-10 | — | — | CN | claimed |
| CN-119034506-A | Composite nanofiltration membrane and preparation method and application thereof | 北京师范大学 | 2024-11-29 | — | — | CN | claimed |
| CN-87101893-A | Ether carboxylate detergent builders and method for making thereof | — | 1987-09-16 | — | — | CN | claimed |
| EP-0232114-A2 | Ether carboxylate detergent builders and process for their preparation | THE PROCTER & GAMBLE COMPANY (US) | 1987-08-12 | — | — | EP | claimed |
| US-4668735-A | MONOSODIUM, MONOPOTASSIUM, MONOAMMONIUM MALEATE; SOLUTION POLYMERIZATION | KAO CORPORATION (JP) | 1987-05-26 | — | — | US | claimed |
| US-4663071-A | TARTRATE MONO AND DISUCCINATES | THE PROCTER & GAMBLE COMPANY (US) | 1987-05-05 | — | — | US | claimed |
| US-4610965-A | Adsorption-desorption purification of glucose isomerase | NABISCO BRANDS, INC. (US) | 1986-09-09 | — | — | US | claimed |
| EP-0185379-A2 | A process for the production of purified glucose isomerase | NABISCO BRANDS, Inc. (US) | 1986-06-25 | — | — | EP | claimed |
| US-4162188-A | IN PRESENCE OF MALEIC ACID OR ITS SODIUM OR POTASSIUM SALT, MESACONIC ACID OR ITS SODIUM SALT, OR MALEIC ANHYDRIDE | HONSHU SEISHI KABUSHIKI KAISHA (JP) | 1979-07-24 | — | — | US | claimed |
| US-4061465-A | Creasable durable press textiles from methylol reagents and half amides or half salts of dicarboxylic acids | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1977-12-06 | — | — | US | claimed |
| US-4040970-A | WITH COPOLYMER FOR RENDERING THE TONER NEGATIVELY CHARGEABLE | CANON KABUSHIKI KAISHA (JA) | 1977-08-09 | — | — | US | claimed |
| US-3977983-A | Liquid developer for use in development of an electrostatic latent image comprising a copolymer containing an amino group converted into a quaternary ammonium salt or hydroxide | CANON KABUSHIKI KAISHA (JA) | 1976-08-31 | — | — | US | claimed |