Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436252 | 0.84 | KMT2A (0.44) | KMT2AMEN1MAPTKDM4EMAPK1 | |
| SCHEMBL3792160 | 0.82 | PLK1 (0.58) | KMT2AMEN1KDM4E | |
| SCHEMBL31060081 | 0.82 | PLK1 (0.58) | KMT2AMEN1KDM4E | |
| SCHEMBL21323506 | 0.80 | GLA (0.49) | KMT2AMEN1KDM4EMAPK1GAA | |
| SCHEMBL28485658 | 0.78 | KMT2A (0.61) | KMT2AMEN1AHRMAPTPRNP | |
| SCHEMBL7838770 | 0.78 | KMT2A (0.54) | KMT2AMEN1AHRMAPTPRNP | |
| SCHEMBL2646933 | 0.76 | KMT2A (0.57) | KMT2AMEN1AHRPRNPKDM4E | |
| SCHEMBL8185833 | 0.76 | KMT2A (0.63) | KMT2AMEN1AHRMAPTPRNP | |
| SCHEMBL29583255 | 0.76 | KMT2A (0.57) | KMT2AMEN1AHRPRNPKDM4E | |
| SCHEMBL30737331 | 0.75 | MEN1 (0.47) | KMT2AMEN1AHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104078-B1 | NAPHTHALENYLTHIAZOLE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1988-07-06 | — | — | EP | disclosed |
| US-4446150-A | TREATING DIABETIC COMPLICATIONS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1984-05-01 | — | — | US | disclosed |