Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646933 | 1.00 | KMT2A (0.57) | KMT2AMEN1AHRPRNPLMNA | |
| SCHEMBL869550 | 0.89 | BRD4 (0.50) | KMT2AMEN1AHRLMNATSHR | |
| SCHEMBL70429 | 0.88 | LMNA (0.59) | KMT2AMEN1LMNATSHRALDH1A1 | |
| SCHEMBL25523280 | 0.86 | SLC6A3 (0.56) | KMT2AMEN1AHRPRNPLMNA | |
| SCHEMBL30848483 | 0.85 | PRNP (0.56) | KMT2AMEN1AHRPRNPALDH1A1 | |
| SCHEMBL4959202 | 0.85 | PRNP (0.56) | KMT2AMEN1AHRPRNPALDH1A1 | |
| SCHEMBL31525357 | 0.82 | KMT2A (0.45) | KMT2AMEN1AHRPRNPLMNA | |
| SCHEMBL29279663 | 0.81 | TSHR (0.52) | KMT2AMEN1LMNATSHRALDH1A1 | |
| SCHEMBL3230050 | 0.81 | NR4A2 (0.53) | LMNATSHRALDH1A1CFTRHSD17B10 | |
| SCHEMBL28485658 | 0.81 | KMT2A (0.61) | KMT2AMEN1AHRPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228625-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |