Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549444 | 0.76 | SMN1; SMN2 (0.40) | MAPTGAAALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL10635587 | 0.68 | CYP1A2 (0.36) | GAACYP2C19CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10468098 | 0.66 | ALDH1A1 (0.44) | MAPTGAAALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL10468461 | 0.66 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL28823761 | 0.64 | NAMPT (0.52) | GAACYP2C19CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL11092419 | 0.63 | ALDH1A1 (0.41) | MAPTGAAALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL30183188 | 0.63 | SMN1; SMN2 (0.51) | MAPTGAAALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL9253861 | 0.63 | CYP3A4 (0.43) | MAPTGAAALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL600477 | 0.62 | CYP3A4 (0.61) | GAACYP2C19CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10470203 | 0.62 | CYP1A2 (0.35) | GAAALDH1A1CYP2C19CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4783463-A | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure | RORER PHARMACEUTICAL CORPORATION (US) | 1988-11-08 | — | — | US | disclosed |