Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547817 | 0.83 | MAPT (0.40) | SMN1; SMN2KDM4EL3MBTL1KMT2AMAPT | |
| SCHEMBL10554712 | 0.79 | MAPT (0.42) | GAAMAPT | |
| SCHEMBL10635580 | 0.76 | MAPT (0.36) | SMN1; SMN2KDM4EL3MBTL1CYP3A4CYP1A2 | |
| SCHEMBL10555290 | 0.76 | RAB9A (0.41) | SMN1; SMN2KDM4EKMT2AGAAMAPT | |
| SCHEMBL10468098 | 0.70 | ALDH1A1 (0.44) | SMN1; SMN2KDM4ECYP3A4CYP1A2CYP2C19 | |
| Morpholine SCHEMBL10535616 | 0.70 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL10550020 | 0.68 | CYP3A4 (0.50) | CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL10635587 | 0.67 | CYP1A2 (0.36) | CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL9253861 | 0.65 | CYP3A4 (0.43) | SMN1; SMN2CYP3A4CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL28823761 | 0.63 | NAMPT (0.52) | CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |