Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10636096 | 0.86 | HPGD (0.52) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL10688192 | 0.73 | PPARG (0.41) | HPGDHIF1AESR1MEN1LMNA | |
| SCHEMBL15378345 | 0.71 | ALOX5 (0.53) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL9579728 | 0.69 | GAA (0.42) | TSHRHSD17B10ESR1MAPK1MEN1 | |
| SCHEMBL10943369 | 0.69 | CYP3A4 (0.46) | HPGDHSD17B10MAPK1NPC1CYP3A4 | |
| SCHEMBL445337 | 0.69 | HSD17B10 (0.46) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL27545982 | 0.68 | HPGD (0.44) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL6231470 | 0.67 | HPGD (0.45) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL8822888 | 0.67 | HSD17B10 (0.76) | HPGDHIF1ATSHRHSD17B10ESR1 | |
| SCHEMBL13577661 | 0.66 | HSD17B10 (0.74) | HPGDHIF1ATSHRHSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4764521-A | Leukotriene antagonists and a method of use there as | ELI LILLY AND COMPANY (US) | 1988-08-16 | — | — | US | disclosed |
| EP-0132367-B1 | LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1988-06-08 | — | — | EP | disclosed |
| EP-0132367-A2 | Leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |