⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580899 | 0.83 | — | — | |
| SCHEMBL4000795 | 0.76 | — | — | |
| SCHEMBL3618069 | 0.75 | — | — | |
| SCHEMBL18154468 | 0.68 | — | — | |
| SCHEMBL6653507 | 0.67 | — | — | |
| SCHEMBL5136626 | 0.64 | CES2 (0.36) | — | |
| SCHEMBL2804056 | 0.64 | — | — | |
| SCHEMBL338700 | 0.63 | — | — | |
| SCHEMBL22645718 | 0.60 | — | — | |
| SCHEMBL6708241 | 0.60 | FAAH (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861726-B1 | RECOMBINANT MICROORGANISM FOR THE FERMENTATIVE PRODUCTION OF METHIONINE | EVONIK DEGUSSA GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-9506093-B2 | Recombinant microorganism for the fermentative production of methionine | METABOLIC EXPLORER (FR) | 2016-11-29 | — | — | US | disclosed |
| US-20150247175-A1 | Recombinant Microorganism for the Fermentative Production of Methionine | EVONIK OPERATIONS GMBH (DE) | 2015-09-03 | — | — | US | disclosed |
| EP-2861726-A1 | RECOMBINANT MICROORGANISM FOR THE FERMENTATIVE PRODUCTION OF METHIONINE | Metabolic Explorer (FR) | 2015-04-22 | — | — | EP | disclosed |
| EP-1747269-B1 | RECOMBINANT ENZYME WITH ALTERED FEEDBACK SENSITIVITY | METABOLIC EXPLORER SA (FR) | 2015-03-25 | — | — | EP | disclosed |
| EP-2780700-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | Memorial Sloan Kettering Cancer Center (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8795990-B2 | Recombinant enzyme with altered feedback sensitivity | METABOLIC EXPLORER (FR) | 2014-08-05 | — | — | US | disclosed |
| WO-2013190343-A1 | RECOMBINANT MICROORGANISM FOR THE FERMENTATIVE PRODUCTION OF METHIONINE | METABOLIC EXPLORER (FR) | 2013-12-27 | — | — | WO | disclosed |
| WO-2013075065-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20110014666-A1 | POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF | METABOLIC EXPLORER (FR) | 2011-01-20 | — | — | US | disclosed |
| EP-2265716-A1 | POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF | Metabolic Explorer (FR) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009115497-A1 | POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF | METABOLIC EXPLORER (FR) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115114-A1 | POLYPEPTIDE HAVING GLYOXYLASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF | METABOLIC EXPLORER (FR) | 2009-09-24 | — | — | WO | disclosed |
| EP-2030975-A1 | CEFDINIR synthesis process | ACS DOBFAR S.p.A. (IT) | 2009-03-04 | — | — | EP | disclosed |
| US-20090029424-A1 | Recombinant enzyme with altered feedback sensitivity | METABOLIC EXPLORER (FR) | 2009-01-29 | — | — | US | disclosed |
| US-20080286840-A1 | Microorganisms Comprising Enzymes Express with Low Gamma-Elimination Activity | METABOLIC EXPLORER (FR) | 2008-11-20 | — | — | US | disclosed |
| EP-1846547-A2 | MICROORGANISMS COMPRISING ENZYMES EXPRESSED WITH LOW GAMMA-ELIMINATION ACTIVITY | Metabolic Explorer (FR) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082254-A2 | MICROORGANISMS COMPRISING ENZYMES EXPRESSED WITH LOW GAMMA-ELIMINATION ACTIVITY | METABOLIC EXPLORER (FR) | 2006-08-10 | — | — | WO | disclosed |
| US-5800979-A | Gas chromatography/mass spectrometric determination of folic acid coenzymes | KOLHOUSE J FRED (US) | 1998-09-01 | — | — | US | disclosed |
| WO-1993017332-A1 | GAS CHROMATOGRAPHY/MASS SPECTROMETRY DETERMINATION OF ASCORBATE AND OXIDATION PRODUCTS THEREOF | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1993-09-02 | — | — | WO | disclosed |