Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 6/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.44 |
| ▸ | HRH1 | P35367 | 6/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | SCN1A | P35498 | 3/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226593 | 0.76 | SMN1; SMN2 (0.47) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL6938022 | 0.76 | HRH1 (0.44) | CHRM2CHRM1HRH1CHRM5CHRM3 | |
| SCHEMBL10632634 | 0.76 | SMN1; SMN2 (0.53) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL11223803 | 0.76 | SMN1; SMN2 (0.47) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL27925029 | 0.75 | SMN1; SMN2 (0.46) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL16999005 | 0.75 | TSHR (0.62) | CHRM2CHRM1HRH1CHRM5CHRM3 | |
| SCHEMBL27779093 | 0.75 | CCR1 (0.48) | CHRM2CHRM1HRH1SLC6A2SLC6A4 | |
| SCHEMBL9149178 | 0.74 | SMN1; SMN2 (0.43) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL10984015 | 0.73 | GAA (0.45) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL27792007 | 0.73 | SMN1; SMN2 (0.49) | CHRM2SLC6A2SLC6A4SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4721710-A | Derivatives of piperidinedione for protecting the myocardium presenting an anti-arrythmic activity, and pharmaceutical compositions | SANOFI | 1988-01-26 | — | — | US | disclosed |
| US-4542134-A | Derivatives of γ-butyrolactone with an anti-arrythmic activity and compositions | SANOFI (FR) | 1985-09-17 | — | — | US | disclosed |
| US-4153797-A | α-Aryl-α, α-bis[ω- (disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4107205-A | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1978-08-15 | — | — | US | disclosed |