Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 8/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MPC2 | O95563 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10639915 | 0.92 | CYP3A4 (0.48) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL7455277 | 0.88 | ALDH1A1 (0.56) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL8496660 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL5672808 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL30050392 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL1536757 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL21630 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL5672813 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL15888838 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL29349864 | 0.86 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139421-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-04-27 | — | — | EP | disclosed |
| US-4572912-A | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1986-02-25 | — | — | US | disclosed |
| EP-0139421-A1 | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-05-02 | — | — | EP | disclosed |