SCHEMBL7455277

SCHEMBL7455277

Cc1cc(C)c2c(c1)OC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)CC2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.56
CYP3A4 P08684 2/20 0.56
MEN1 O00255 2/20 0.56
MAPT P10636 2/20 0.56
KMT2A Q03164 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
TP53 P04637 1/20 0.56
CYP1A2 P05177 1/20 0.56
HPGD P15428 1/20 0.56
ALOX15 P16050 1/20 0.56
TSHR P16473 1/20 0.56
HSD17B10 Q99714 1/20 0.56
FFAR1 O14842 6/20 0.47
PPARA Q07869 2/20 0.45
MAOA P21397 1/20 0.44
CISD1 Q9NZ45 1/20 0.44
PPARG P37231 8/20 0.43
HRH3 Q9Y5N1 1/20 0.43
MPC2 O95563 1/20 0.43
CYP2C8 P10632 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10639005 0.88 MEN1 (0.54) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL7842499 0.86 MEN1 (0.56) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL9533227 0.84 ALDH1A1 (0.53) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL10638937 0.83 ALDH1A1 (0.55) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL9532951 0.83 MEN1 (0.58) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL9531002 0.81 MEN1 (0.59) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL8021469 0.81 MEN1 (0.51) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL10639049 0.81 CYP3A4 (0.56) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL9531273 0.81 MEN1 (0.58) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL9531264 0.81 MEN1 (0.58) ALDH1A1CYP3A4MEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804193-A4 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS KURTZ THEODORE W (US) 2002-03-27 EP disclosed
US-6110951-A LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS BETHESDA PHARMACEUTICALS, INC. 2000-08-29 US disclosed
EP-0804193-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-11-05 EP disclosed
US-5594015-A Thiazolidine derivatives for the treatment of psoriasis REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-01-14 US disclosed
WO-1995035108-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-12-28 WO disclosed
EP-0277836-B1 THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE Sankyo Company Limited (JP) 1993-06-02 EP disclosed
US-5053420-A Antidiabetic agents KURTZ, THEODORE W. 1991-10-01 US disclosed
WO-1991005538-A2 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION PERSHADSINGH HARRIHAR A (US) 1991-05-02 WO disclosed
US-4873255-A REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS SANKYO COMPANY LIMITED (JP) 1989-10-10 US disclosed
EP-0277836-A1 Thiazolidinone derivatives, their preparation and their use Sankyo Company Limited (JP) 1988-08-10 EP disclosed