Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | PRF1 | P14222 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | NAT1 | P18440 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064121 | 1.00 | TDP1 (0.75) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL5142931 | 0.86 | PIK3CG (0.61) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL5142934 | 0.86 | PIK3CG (0.61) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL12931803 | 0.86 | PIM1 (0.63) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL623594 | 0.86 | TDP1 (0.60) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL14860890 | 0.86 | TDP1 (1.00) | TDP1PRF1MEN1KMT2A | |
| SCHEMBL14860889 | 0.86 | TDP1 (1.00) | TDP1PRF1MEN1KMT2A | |
| SCHEMBL14860888 | 0.86 | TDP1 (1.00) | TDP1PRF1MEN1KMT2A | |
| SCHEMBL12961661 | 0.86 | PRF1 (0.59) | TDP1PRF1PIM1PIM3PIM2 | |
| SCHEMBL623593 | 0.86 | TDP1 (0.60) | TDP1PRF1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2008-03-27 | — | — | US | disclosed |
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7294641-B2 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | L'OREAL (FR) | 2007-11-13 | — | — | US | disclosed |
| US-7294641-B2 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | L'OREAL (FR) | 2007-11-13 | — | — | US | disclosed |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | KRT18, FGF1, SHH | TDP1 4001/4885PRF1 2632/4885PIM1 4417/4885 |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | COX15, HPGD, TYR | TDP1 2202/4885PRF1 3750/4885PIM1 2801/4885 |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | COX15, HPGD, TYR | TDP1 2202/4885PRF1 3750/4885PIM1 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.