Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076745 | 0.90 | PI4KB (0.62) | PI4KBMAPK14CYP3A4ABL1EGFR | |
| SCHEMBL11244642 | 0.85 | PI4KB (0.48) | PI4KBCYP3A4KMT2A | |
| SCHEMBL11148680 | 0.83 | SMN1; SMN2 (0.39) | PI4KBMAPK14KMT2A | |
| SCHEMBL10643033 | 0.82 | PI4KB (0.61) | PI4KBMAPK14CYP3A4ABL1MAPK1 | |
| SCHEMBL18058988 | 0.80 | PI4KB (0.49) | PI4KBMAPK14CYP3A4ABL1EGFR | |
| SCHEMBL18058954 | 0.80 | MAPK14 (0.47) | PI4KBMAPK14CYP3A4ABL1EGFR | |
| SCHEMBL10640202 | 0.78 | PI4KB (0.47) | PI4KBMAPK14CYP3A4KMT2A | |
| SCHEMBL11180034 | 0.76 | PI4KB (0.57) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11180038 | 0.76 | PI4KB (0.57) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11258832 | 0.75 | PI4KB (0.59) | PI4KBMAPK14CYP3A4ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091794-B1 | PROCESS FOR PREPARING 1.6-DISUBSTITUTED 2-AMINOBENZIMIDAZOLES | ELI LILLY AND COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| US-4434288-A | Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles | ELI LILLY AND COMPANY (US) | 1984-02-28 | — | — | US | disclosed |
| EP-0091794-A1 | Process for preparing 1.6-disubstituted 2-aminobenzimidazoles | ELI LILLY AND COMPANY (US) | 1983-10-19 | — | — | EP | disclosed |