Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643008 | 0.80 | OPRL1 (0.47) | OPRL1POLBSIGMAR1DRD2DRD4 | |
| SCHEMBL29017450 | 0.80 | LMNA (0.47) | LMNAGAASIGMAR1KMT2A | |
| SCHEMBL5242779 | 0.79 | OPRL1 (0.67) | OPRL1POLBSIGMAR1DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10652811 | 0.79 | POLB (0.49) | OPRL1POLBSIGMAR1DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10750648 | 0.78 | POLB (0.68) | OPRL1POLBSIGMAR1DRD2DRD4 | |
| SCHEMBL7256584 | 0.77 | SIGMAR1 (0.57) | OPRL1POLBSIGMAR1 | |
| Bromide SCHEMBL7248470 | 0.75 | SIGMAR1 (0.56) | OPRL1POLBSIGMAR1 | |
| SCHEMBL11171872 | 0.75 | KCNA3 (0.43) | OPRL1POLBSIGMAR1DRD2DRD4 | |
| SCHEMBL7252976 | 0.74 | SIGMAR1 (0.70) | OPRL1SIGMAR1KMT2A | |
| Bromide SCHEMBL7252777 | 0.73 | SIGMAR1 (0.68) | OPRL1SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0192521-B1 | 3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-12-14 | — | — | EP | claimed |
| EP-0192521-A1 | 3-Phenyl-tetrahydropyridine derivatives, process for their preparation and their therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | claimed |
| EP-0192522-A1 | 1-ethyl- 3-hydroxy-3-phenylpiperidine, process for its preparation and its therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | claimed |
| EP-0192521-B1 | 3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-12-14 | — | — | EP | disclosed |
| US-4680302-A | ANTIDEPRESSANTS | LABORATOIRE L. LAFON (FR) | 1987-07-14 | — | — | US | disclosed |
| US-4680302-A | ANTIDEPRESSANTS | LABORATOIRE L. LAFON (FR) | 1987-07-14 | — | — | US | disclosed |
| US-4680302-A | ANTIDEPRESSANTS | LABORATOIRE L. LAFON (FR) | 1987-07-14 | — | — | US | disclosed |
| US-4663328-A | 3-Phenyl-tetrahydropyridine derivatives, and their use as sedative agents | LABORATOIRE L. LAFON (FR) | 1987-05-05 | — | — | US | disclosed |
| EP-0192521-A1 | 3-Phenyl-tetrahydropyridine derivatives, process for their preparation and their therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |
| EP-0192522-A1 | 1-ethyl- 3-hydroxy-3-phenylpiperidine, process for its preparation and its therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |
| EP-0192522-A1 | 1-ethyl- 3-hydroxy-3-phenylpiperidine, process for its preparation and its therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |