Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642060 | 0.85 | ESR1 (0.42) | TSHRESR1ESR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL10644288 | 0.80 | CNR2 (0.43) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL10658011 | 0.80 | PPARA (0.59) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL10643064 | 0.79 | ALDH1A1 (0.40) | ABCB11CYP1A2CYP3A4TSHRHTR2A | |
| SCHEMBL10660557 | 0.73 | ALDH2 (0.50) | ESR1ESR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10658226 | 0.72 | AR (0.53) | CYP1A2TSHRESR1ESR2SMN1; SMN2 | |
| SCHEMBL10737449 | 0.71 | ALDH1A1 (0.51) | CYP1A2CYP3A4TSHRESR1ESR2 | |
| SCHEMBL10656236 | 0.71 | ALDH2 (0.46) | PPARAESR1ESR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL10660550 | 0.70 | PPARA (0.43) | CYP1A2CYP3A4PPARAESR1ESR2 | |
| SCHEMBL10658222 | 0.70 | ESR1 (0.41) | CYP1A2CYP3A4PPARAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147691-B1 | ANTIHYPERTENSIVE 3-ARYL-1,2-BENZISOXAZOLSULFONYL AND-SULFINYL-ALKANOIC ACIDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4602028-A | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0147691-A1 | Antihypertensive 3-aryl-1,2-benzisoxazolsulfonyl and-sulfinyl-alkanoic acids, a process for their preparation and their use for the preparation of medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |