Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CDH1 | P12830 | 1/20 | 0.34 |
| ▸ | APC | P25054 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643453 | 0.85 | ABCB11 (0.38) | ESR1ESR2ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL10643046 | 0.77 | CNR2 (0.45) | ESR1ESR2ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL11464599 | 0.77 | PPARA (0.41) | KMT2A | |
| SCHEMBL10662939 | 0.76 | PPARA (0.55) | ESR1ESR2KMT2A | |
| SCHEMBL10647792 | 0.76 | SLC22A12 (0.43) | ESR1ESR2ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL8417184 | 0.75 | PPARA (0.44) | KMT2ATSHR | |
| SCHEMBL10660550 | 0.73 | PPARA (0.43) | ESR1ESR2KMT2A | |
| SCHEMBL13069472 | 0.73 | PPARA (0.53) | ALDH1A1KMT2ACDH1CTNNB1TCF7L2 | |
| SCHEMBL10658222 | 0.72 | ESR1 (0.41) | ESR1ESR2ALDH1A1KMT2ACDH1 | |
| SCHEMBL4745564 | 0.70 | ESR1 (0.81) | ESR1ESR2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147691-B1 | ANTIHYPERTENSIVE 3-ARYL-1,2-BENZISOXAZOLSULFONYL AND-SULFINYL-ALKANOIC ACIDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4602028-A | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0147691-A1 | Antihypertensive 3-aryl-1,2-benzisoxazolsulfonyl and-sulfinyl-alkanoic acids, a process for their preparation and their use for the preparation of medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |