Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 3/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647935 | 0.87 | GRM8 (0.49) | GRM8GRM4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10645654 | 0.84 | GRM8 (0.52) | GRM8GRM4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10645930 | 0.84 | GRM8 (0.45) | GRM8GRM4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10647825 | 0.82 | KCNH2 (0.46) | GRM8GRM4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL10645819 | 0.80 | HTR2A (0.38) | SMN1; SMN2 | |
| SCHEMBL10647905 | 0.78 | MAPT (0.46) | GRM8GRM4LMNAHTTSMN1; SMN2 | |
| SCHEMBL10645248 | 0.76 | SMN1; SMN2 (0.44) | GRM8GRM4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10650137 | 0.75 | MAPT (0.46) | GRM8GRM4LMNA | |
| SCHEMBL19339253 | 0.73 | L3MBTL1 (0.60) | GRM8GRM4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL24194434 | 0.73 | SMN1; SMN2 (0.50) | GRM8GRM4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4752621-A | Arylalkyl amines useful for lowering intraocular pressure | SYNTEX (U.S.A.) INC. (US) | 1988-06-21 | — | — | US | disclosed |
| US-4642378-A | Arylalkyl amines useful for lowering intraocular pressure | SYNTEX (U.S.A.) INC. (US) | 1987-02-10 | — | — | US | disclosed |