Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10645654 | 0.81 | GRM8 (0.52) | SMN1; SMN2L3MBTL1HTTGRM8GRM4 | |
| SCHEMBL10647935 | 0.80 | GRM8 (0.49) | SMN1; SMN2L3MBTL1HTTACP3GRM8 | |
| SCHEMBL10647887 | 0.79 | LMNA (0.41) | L3MBTL1GRM8GRM4LMNACYP2C9 | |
| SCHEMBL10648100 | 0.78 | HTT (0.45) | L3MBTL1HTTGRM8GRM4LMNA | |
| SCHEMBL10646343 | 0.78 | AOC3 (0.41) | HTTCYP3A4ALDH1A1KDM4E | |
| SCHEMBL10349304 | 0.78 | POLB (0.47) | ALDH1A1KDM4E | |
| SCHEMBL19339253 | 0.77 | L3MBTL1 (0.60) | SMN1; SMN2L3MBTL1HTTACP3GRM8 | |
| SCHEMBL10644965 | 0.76 | GRM8 (0.42) | SMN1; SMN2L3MBTL1HTTGRM8GRM4 | |
| SCHEMBL10648725 | 0.76 | CTSV (0.45) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL28490652 | 0.76 | L3MBTL1 (0.46) | SMN1; SMN2L3MBTL1HTTACP3GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4752621-A | Arylalkyl amines useful for lowering intraocular pressure | SYNTEX (U.S.A.) INC. (US) | 1988-06-21 | — | — | US | disclosed |
| US-4642378-A | Arylalkyl amines useful for lowering intraocular pressure | SYNTEX (U.S.A.) INC. (US) | 1987-02-10 | — | — | US | disclosed |