Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646020 | 1.00 | KCNH2 (0.50) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL9483294 | 0.90 | TDP1 (0.51) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL9483310 | 0.90 | TDP1 (0.51) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL10897232 | 0.89 | KCNH2 (0.39) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL10646060 | 0.89 | TDP1 (0.53) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL10646054 | 0.89 | TDP1 (0.53) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL10644408 | 0.88 | KCNH2 (0.52) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL10644409 | 0.88 | KCNH2 (0.52) | KCNH2TDP1APAF1LMNATSHR | |
| SCHEMBL11055001 | 0.87 | ABCC4 (0.48) | KCNH2TDP1TSHRL3MBTL1CTDSP1 | |
| SCHEMBL11055004 | 0.87 | ABCC4 (0.48) | KCNH2TDP1TSHRL3MBTL1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057422-B1 | NEW CEPHEM COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-10-12 | — | — | EP | disclosed |
| EP-0191507-A2 | New 2-oxyimino-3-oxobutyric acid derivatives and process for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-08-20 | — | — | EP | disclosed |
| US-4452851-A | BACTERICIDES, ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-05 | — | — | US | disclosed |
| EP-0057422-A2 | New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-08-11 | — | — | EP | disclosed |