Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407273 | 0.89 | LMNA (0.52) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18384626 | 0.83 | LMNA (0.54) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10648703 | 0.80 | LMNA (0.50) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7055897 | 0.78 | PDE4A (0.53) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9819399 | 0.77 | MAPT (0.37) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14936651 | 0.77 | LMNA (0.54) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7051399 | 0.77 | PDE4A (0.55) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14981193 | 0.76 | LMNA (0.56) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7055204 | 0.76 | LMNA (0.48) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10861072 | 0.74 | NPC1 (0.41) | LMNAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187387-B1 | BENZOFURAN DERIVATIVE, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |
| EP-0187387-A1 | Benzofuran derivative, process for preparing the same and pharmaceutical composition containing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1986-07-16 | — | — | EP | disclosed |