Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819208 | 0.86 | TSHR (0.40) | MAPTCTPS1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10646339 | 0.77 | LMNA (0.46) | MAPTALDH1A1HTTKDM4ETSHR | |
| SCHEMBL9819188 | 0.73 | DAO (0.38) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL26144884 | 0.72 | MAPT (0.47) | MAPTALDH1A1HTTKDM4ETSHR | |
| SCHEMBL9819407 | 0.72 | SMN1; SMN2 (0.34) | MAPTCTPS1ALDH1A1KDM4ETSHR | |
| SCHEMBL27185630 | 0.70 | MAPT (0.40) | MAPTALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL9818958 | 0.70 | MCL1 (0.40) | MAPTALDH1A1TSHR | |
| SCHEMBL9818989 | 0.70 | MAPT (0.41) | MAPTALDH1A1HTTKDM4ETSHR | |
| SCHEMBL21798603 | 0.68 | GAA (0.46) | MAPTCTPS1ALDH1A1HTTKDM4E | |
| SCHEMBL23461897 | 0.68 | MAPT (0.42) | MAPTALDH1A1HTTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312338-B1 | SULFAMOYL-2-BENZOFURANCARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4918206-A | DIURETICS, HYPOTENSIVE AGENTS; SIDE EFFECT REDUCTION | SHIONOGI & CO., LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| EP-0312338-A1 | Sulfamoyl-2-benzofurancarboxylic acid derivatives, their preparation and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-04-19 | — | — | EP | disclosed |