Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | ADH5 | P11766 | 1/20 | 0.30 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649836 | 0.83 | PDE3B (0.35) | POLBNPC1MITFDNMT1HTT | |
| SCHEMBL10645524 | 0.71 | PDE3B (0.61) | POLBKMT2APDE3BPDE3AADH5 | |
| SCHEMBL11104830 | 0.69 | PDE3B (0.36) | KMT2APDE3BPDE3AADH5 | |
| SCHEMBL11099822 | 0.67 | PDE3B (0.34) | PDE3BPDE3AADH5 | |
| SCHEMBL10363287 | 0.67 | PDE4A (0.42) | PDE3BPDE3AADH5 | |
| SCHEMBL11101097 | 0.66 | CYP3A4 (0.34) | PDE3BPDE3A | |
| SCHEMBL10647436 | 0.66 | PDE3B (0.44) | PDE3BPDE3AADH5 | |
| SCHEMBL10363632 | 0.65 | PDE3B (0.38) | PDE3BPDE3A | |
| SCHEMBL10365674 | 0.65 | PDE3B (0.45) | POLBKMT2APDE3BPDE3AADH5 | |
| SCHEMBL10364015 | 0.65 | PDE3B (0.41) | POLBKMT2APDE3BPDE3AADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |