Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.61 |
| ▸ | ADH5 | P11766 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647436 | 0.79 | PDE3B (0.44) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL11020022 | 0.79 | PDE3B (0.50) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL11020025 | 0.79 | PDE3B (0.50) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL10648271 | 0.78 | PDE3A (0.59) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10648980 | 0.78 | PDE3B (0.41) | PDE3BPDE3APIM1GPR119MET | |
| SCHEMBL10648014 | 0.78 | PDE3B (0.41) | PDE3BPDE3AGPR119METPDGFRB | |
| SCHEMBL10649130 | 0.78 | PDE3B (0.65) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL10364015 | 0.78 | PDE3B (0.41) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL7290528 | 0.76 | PDE3B (1.00) | PDE3BPDE3AADH5PDE2APDE4A | |
| SCHEMBL11104830 | 0.76 | PDE3B (0.36) | PDE3BPDE3AADH5CLK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |