Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ADH5 | P11766 | 8/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099822 | 0.84 | PDE3B (0.34) | PDE3BPDE3AADH5CYP3A4CYP1A2 | |
| SCHEMBL11102889 | 0.78 | PDE3B (0.38) | PDE3BPDE3AADH5CYP3A4MAPT | |
| SCHEMBL11104630 | 0.78 | CYP3A4 (0.34) | PDE3BPDE3ACYP3A4MAPTLMNA | |
| SCHEMBL11101097 | 0.77 | CYP3A4 (0.34) | PDE3BPDE3ACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10645524 | 0.76 | PDE3B (0.61) | PDE3BPDE3AADH5MAPTALOX15 | |
| SCHEMBL11101040 | 0.76 | PDE3B (0.57) | PDE3BPDE3AADH5CYP3A4MAPT | |
| SCHEMBL28061806 | 0.71 | CYP3A4 (0.50) | ADH5CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29241982 | 0.70 | CYP3A4 (0.42) | CYP3A4CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL10646469 | 0.69 | POLB (0.35) | PDE3BPDE3AADH5KMT2A | |
| SCHEMBL10647436 | 0.69 | PDE3B (0.44) | PDE3BPDE3AADH5CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |