Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646647 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Cinepazide SCHEMBL8839976 | 0.93 | ALDH1A1 (0.77) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Cinepazide SCHEMBL34092 | 0.93 | ALDH1A1 (0.77) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Cinepazide SCHEMBL11009911 | 0.90 | KDM4E (0.72) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Cinepazide SCHEMBL27666991 | 0.89 | KDM4E (0.71) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Cinepazide SCHEMBL1062368 | 0.89 | KDM4E (0.71) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| SCHEMBL28790703 | 0.89 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| SCHEMBL6785718 | 0.89 | ALDH1A1 (0.76) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| SCHEMBL25309070 | 0.89 | ALDH1A1 (0.80) | KDM4EALDH1A1HPGDKMT2ACYP3A4 | |
| Fumaric Acid SCHEMBL11710489 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1HPGDKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175331-B1 | PIPERAZINE DERIVATIVES | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1988-11-17 | — | — | EP | disclosed |
| US-4656172-A | CONTROLLING OR PREVENTING CEREBRAL, CORONARY OR PERIPHIPHERAL VASCULAR DISORDER | TERUMO KABUSHIKI KAISHA (JP) | 1987-04-07 | — | — | US | disclosed |
| US-4656172-A | CONTROLLING OR PREVENTING CEREBRAL, CORONARY OR PERIPHIPHERAL VASCULAR DISORDER | TERUMO KABUSHIKI KAISHA (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0175331-A1 | Piperazine Derivatives | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1986-03-26 | — | — | EP | disclosed |
| EP-0175331-A1 | Piperazine Derivatives | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1986-03-26 | — | — | EP | disclosed |