Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.43 |
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643064 | 0.85 | ALDH1A1 (0.40) | SLC22A12ESR1ESR2PPARAALDH1A1 | |
| SCHEMBL10662939 | 0.77 | PPARA (0.55) | SLC22A12ESR1ESR2PPARAPPARG | |
| SCHEMBL10648536 | 0.76 | HTT (0.42) | ESR1ESR2PPARAPPARGALDH1A1 | |
| SCHEMBL10642060 | 0.76 | ESR1 (0.42) | ESR1ESR2ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL10643046 | 0.76 | CNR2 (0.45) | ESR1ESR2ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL13069472 | 0.73 | PPARA (0.53) | SLC22A12PPARAPPARGALDH1A1KMT2A | |
| SCHEMBL10660550 | 0.73 | PPARA (0.43) | ESR1ESR2PPARAPPARGKMT2A | |
| SCHEMBL4398676 | 0.73 | PPARA (0.51) | SLC22A12PPARAPPARGALDH1A1KMT2A | |
| SCHEMBL10658222 | 0.73 | ESR1 (0.41) | ESR1ESR2PPARAPPARGALDH1A1 | |
| SCHEMBL10737449 | 0.73 | ALDH1A1 (0.51) | ESR1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | claimed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0147691-B1 | ANTIHYPERTENSIVE 3-ARYL-1,2-BENZISOXAZOLSULFONYL AND-SULFINYL-ALKANOIC ACIDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| US-4602028-A | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0147691-A1 | Antihypertensive 3-aryl-1,2-benzisoxazolsulfonyl and-sulfinyl-alkanoic acids, a process for their preparation and their use for the preparation of medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |