Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | POLA1 | P09884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376957 | 0.82 | NOS3 (0.36) | GAAKMT2AKDM4ECYP2D6CYP2C19 | |
| SCHEMBL14689392 | 0.81 | MAPT (0.42) | GAAKMT2AMAPTPKMKDM4E | |
| SCHEMBL1319508 | 0.79 | KMT2A (0.38) | GAAKMT2AKDM4ECYP2C19LMNA | |
| SCHEMBL21539005 | 0.78 | GAA (0.46) | GAAKMT2AMAPTPKMKDM4E | |
| SCHEMBL11680710 | 0.78 | CDK2 (0.35) | GAAKMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL10645996 | 0.77 | CYP2D6 (0.33) | GAAKMT2AMAPTPKMKDM4E | |
| SCHEMBL11278078 | 0.75 | CYP2D6 (0.61) | GAAKMT2APKMKDM4EALDH1A1 | |
| SCHEMBL2721693 | 0.74 | KMT2A (0.46) | GAAKMT2AMAPTPKMKDM4E | |
| SCHEMBL8112266 | 0.73 | POLB (0.41) | GAAKMT2AMAPTALDH1A1CYP2D6 | |
| SCHEMBL31373525 | 0.73 | ALDH1A1 (0.41) | GAAKMT2AMAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0121341-B1 | TRIAZOLO(4,3-C)PYRIMIDINES AND TRIAZOLO(1,5-C)PYRIMIDINES SUBSTITUTED BY NITROGEN-CONTAINING HETEROCYCLIC RINGS | RIKER LABORATORIES, INCORPORATED (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4591588-A | Triazolo[1,5-c]pyrimidines and bronchodilation use thereof | RIKER LABORATORIES, INC. (US) | 1986-05-27 | — | — | US | disclosed |
| US-4572910-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1986-02-25 | — | — | US | disclosed |
| US-4536579-A | BRONCHODILATING AGENTS | RIKER LABORATORIES, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4477450-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0121341-A1 | Triazolo(4,3-c)pyrimidines and triazolo(1,5-c)pyrimidines substituted by nitrogen-containing heterocyclic rings | RIKER LABORATORIES, INCORPORATED (US) | 1984-10-10 | — | — | EP | disclosed |