SCHEMBL10648487

SCHEMBL10648487

Oc1ccc2c(c1)oc1cc(Cl)c(Cl)cc12

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.72
ALDH1A1 P00352 2/20 0.72
HSD17B10 Q99714 2/20 0.72
LMNA P02545 1/20 0.72
MAPT P10636 1/20 0.72
ALOX15 P16050 1/20 0.72
HTT P42858 1/20 0.72
SMN1; SMN2 Q16637 1/20 0.72
AHR P35869 5/20 0.64
PDE2A O00408 1/20 0.52
HSD17B3 P37058 2/20 0.49
PKLR P30613 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
MAOA P21397 1/20 0.49
CA12 O43570 2/20 0.47
CA9 Q16790 2/20 0.47
KMT2A Q03164 1/20 0.47
DYRK1A Q13627 1/20 0.46
ESR1 P03372 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29600967 0.85 KDM4E (1.00) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL3874542 0.85 KDM4E (1.00) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL10913158 0.82 KDM4E (0.75) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL11831965 0.81 KDM4E (0.82) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL10646422 0.81 KDM4E (0.67) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL29403123 0.80 AHR (1.00) LMNAAHRNPSR1RXFP1
SCHEMBL548471 0.80 AHR (1.00) LMNAAHRNPSR1RXFP1
SCHEMBL2278885 0.79 AHR (0.77) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL2768245 0.77 AHR (0.61) KDM4EALDH1A1HSD17B10LMNAMAPT
SCHEMBL24343623 0.76 ALDH1A1 (0.59) KDM4EALDH1A1HSD17B10LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0155574-B1 PYRIDINIUM SALTS AND FUNGICIDES AND BACTERICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1988-08-24 EP disclosed
EP-0094566-B1 DIBENZOFURANYLOXYALKANE-IMIDAZOLIUM SALTS, PROCESS FOR THEIR PREPARATION AND THEIR MICROBICIDAL APPLICATION BASF Aktiengesellschaft (DE) 1986-03-12 EP disclosed
EP-0155574-A1 Pyridinium salts and fungicides and bactericides containing them BASF Aktiengesellschaft (DE) 1985-09-25 EP disclosed
US-4497819-A BACTERICIDES, FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1985-02-05 US disclosed
EP-0057362-B1 DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES BASF Aktiengesellschaft (DE) 1984-06-20 EP disclosed
EP-0103277-A1 Quaternary ammonium salts of benzofuran derivatives and fungicides containing them BASF Aktiengesellschaft (DE) 1984-03-21 EP disclosed
EP-0094566-A1 Dibenzofuranyloxyalkane-imidazolium salts, process for their preparation and their microbicidal application BASF Aktiengesellschaft (DE) 1983-11-23 EP disclosed
US-4376776-A Dibenzofuran derivatives and their use for controlling fungi BASF AKTIENGESELLSCHAFT (DE) 1983-03-15 US disclosed
EP-0057362-A1 Dibenzofurane derivatives, process for their preparation and their use as fungicides BASF Aktiengesellschaft (DE) 1982-08-11 EP disclosed