Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 3/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290756 | 0.90 | GCK (0.38) | CACNA1GCACNA1HCACNA1IP2RX3 | |
| SCHEMBL4290753 | 0.90 | GCK (0.38) | CACNA1GCACNA1HCACNA1IP2RX3 | |
| SCHEMBL1061639 | 0.90 | CACNA1G (0.36) | CACNA1GCACNA1HCACNA1IP2RX3MAPK14 | |
| SCHEMBL1081459 | 0.84 | CACNA1G (0.34) | CACNA1GCACNA1HCACNA1IP2RX3MAPK14 | |
| SCHEMBL1064925 | 0.83 | CACNA1G (0.33) | CACNA1GCACNA1HCACNA1IP2RX3MAPK14 | |
| SCHEMBL1064693 | 0.83 | CACNA1G (0.35) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1059628 | 0.83 | CACNA1G (0.35) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1081198 | 0.83 | ALDH1A1 (0.31) | — | |
| SCHEMBL1062637 | 0.82 | CACNA1G (0.36) | CACNA1GCACNA1HCACNA1IP2RX3MAPK14 | |
| SCHEMBL4294373 | 0.82 | CACNA1G (0.36) | CACNA1GCACNA1HCACNA1IP2RX3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268633-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009127544-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |