Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432670 | 0.74 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL29405082 | 0.74 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL6639863 | 0.72 | NPC1 (0.61) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL10562402 | 0.71 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL23691408 | 0.71 | NPC1 (0.60) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL10649994 | 0.70 | NPC1 (0.54) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9056336 | 0.70 | RAB9A (0.54) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL11445226 | 0.69 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL6130015 | 0.69 | CYP1A2 (0.63) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL10564648 | 0.69 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120589-B1 | IMIDAZO-HETEROCYCLIC COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |
| US-4621084-A | CARDIOTONIC, ANTIULCER | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-04 | — | — | US | disclosed |
| EP-0120589-A1 | Imidazo-heterocyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-03 | — | — | EP | disclosed |