SCHEMBL10650055

SCHEMBL10650055

O=C(O)Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM7 Q14831 3/20 0.42
GRM4 Q14833 3/20 0.42
PPOX P50336 1/20 0.42
GRM1 Q13255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9266591 0.85 GRM7 (0.44) GRM7GRM4
SCHEMBL10541662 0.79 GRM7 (0.40) GRM7GRM4PPOXGRM1
SCHEMBL10573086 0.79 GRM7 (0.39) GRM7GRM4PPOX
SCHEMBL9444941 0.78 PPOX (0.64) GRM7GRM4PPOXGRM1
SCHEMBL10535064 0.75 PPOX (0.44) GRM7GRM4PPOXGRM1
SCHEMBL10719745 0.72 GRM7 (0.46) GRM7GRM4PPOX
SCHEMBL7891292 0.72 PPOX (0.46) GRM7GRM4PPOXGRM1
SCHEMBL10573081 0.72 GRM7 (0.44) GRM7GRM4PPOX
SCHEMBL10575539 0.72 GRM7 (0.44) GRM7GRM4PPOX
SCHEMBL30835160 0.72 CXCL8 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0126419-B1 2-SUBSTITUTED PHENYL-4,5,6,7-TETRAHYDRO-2H-ISOINDOLE-1,3-DIONES, AND THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-08-17 EP disclosed