Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 9/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881184 | 0.72 | PIM1 (0.39) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL9210120 | 0.70 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL4337278 | 0.67 | PIM1 (0.49) | MAPTGAAFYN | |
| SCHEMBL4331345 | 0.64 | CAMK2D (0.41) | MEN1KMT2ACAMK2DKCNH2NFKB1 | |
| SCHEMBL8686454 | 0.63 | PLAT (0.39) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL2345970 | 0.62 | ALDH1A1 (0.69) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL20805585 | 0.62 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14626213 | 0.62 | RPS6KB2 (0.47) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL24147766 | 0.61 | PIK3CA (0.46) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL25994206 | 0.61 | MAPT (0.40) | NPC1RAB9AMEN1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |