Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | USP10 | Q14694 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970519 | 0.86 | ATM (0.46) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL1970520 | 0.86 | ATM (0.46) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL10652736 | 0.82 | PDK1 (0.47) | PDK1KCNMA1ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL12919832 | 0.80 | PDK1 (0.54) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL3760816 | 0.78 | ATM (0.50) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL3528402 | 0.76 | ATM (0.49) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL3528404 | 0.76 | ATM (0.49) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL10651196 | 0.75 | MAPT (0.47) | TDP1ATMPDK1MAPTALDH1A1 | |
| SCHEMBL21624288 | 0.75 | ATM (0.55) | TDP1ATMPDK1KCNMA1MAPT | |
| SCHEMBL30006044 | 0.75 | ATM (0.55) | TDP1ATMPDK1KCNMA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |